Volcanic soils, such as Andisols, form from the weathering of volcanic ash and rocks. The specific mineralogical properties of these soils make them rich in nutrient, and thus highly fertile and beneficial for agriculture. On the other hand, the distribution of soils formed from volcanic ash in East Africa is tightly related to a Neglected Tropical Disease (NTD) known as podoconiosis, a disease impairing the lymphatic system and leading to the abnormal elephant-like inflammation of patient legs and feet, causing pain, severe disability and social stigma. While climate is an essential driver for volcanic soil evolution and their seeding with volcanic ash, little is known about the effect of climate change on the fertility of these soils, or their propencity to release particles favoring the development of podoconiosis. In this project, we aim to better understand the weathering of volcanic ash soils under various climatic scenarios. Another goal is to identify fine soil particles likely to penetrate the skin and trigger immune responses, lymphatic obstruction, and Podoconiosis, either in soil material or bioaccumulated in the feet and lymph nodes of podoconiosis patients.